녹차 및 결명자 추출물의 치주조직병 원인균에 대한 억제효과
Restraint effect on leaf-extract from Camellia sinensis and seed-extract from Casia tora against periodontopathogens
소속 상세정보
이은숙/Lee, Eun-Sook
안태영/윤정중/국중기/이병래/김동기/Ahn, Tae-Young/Yoon, Jeong-Joong/Kook, Joong-Ki/Lee, Byoung Rai/Kim, Dong-Kie
KMID : 0355420030270040569
Abstract
It is known that the periodontal disease is caused by infection of inner oral bacteria as a suffering disease to human mankind for a long time. It can make the various clinical symptoms such as gingival bleeding, formation of periodontal pocket, loss of attached gingiva, collapse of alveolar bone and halitosis, and is known to the major contributor of loss of teeth. This study investigated the growth restraint effect of Camellia sinensis and Casia tora. As a result of study, the minimum restraint concentration of standard microbe on F. nudeatum for extracts from C, sinensis showed 2.5, 0.63 and 1.25 mg/ml, respectively and minimum restraint concentration of clinical separation microbe on F. nucleatum for extracts from C. sinensis showed 2.5 and 5.0 mg/ml. The minimum restraint concentration of standard microbe and clinical separation microbe for P. intermedia, P. nigrescens, P. gingivaGs and P. endodontalis showed above 5.0, 5.0, 2.5-5.0 and 5.0 mg/ml for standard microbe and 1.25, 5.0, various value and 5.0 mg/ml for clinical separation microbe, respectively. Meanwhile, the minimum restraint concentration of standard microbe and clinical separation microbe on F, nudeatum for extracts from C. torn showed 2.5 and 2.5-5.0 mg/ml, respectively. The minimum restraint concentration of standard microbe and clinical separation microbe for P. intermedia, P. nigrescens, P. gingivalis, and P. endodontalis showed above 5.0 mg/ml for standard microbe and above 5.0 mg/ml for clinical separation microbe, respectively. As a result of investigating the cell-toxicity for each extracts, extracts from C sinensis does not showed the toxicity for the cell below the concentration of 2.5 mg/ml, but it showed toxicity for the cell above concentration of 2.5 mg/ml and it decreased the existence ratio for the cell. Meanwhile, in the case of C. tom, it increased the multiplication ratio below the concentration of 1.25 mg/ml compared to the subject group and it decreased gradually the multiplication ratio that the growth ratio for the cell is increased better than subject group. As a result of this study, extracts from C. sinensis was more effect on the growth restraint effect against periodontopathogens than extracts from C. tora and is proven that it is possible for use as a oral mouthrinsing liquids in the near future. On the basis of results of this study, it is judged that the study for restraint reaction mechanism and discrete clinical test for implementation should be needed.
키워드
결명자 추출물;녹차 추출물;치주조직병 원인균;항균효과;Antibacterial effect;Camellia sinensis;Casia tora;periodontopathogens
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